Lothbury is the name of the street that runs along the North Side of the Bank of England, and there has been a church on the current site as early as the 12th Century. It was rebulit in 1440, largely at the expense of Robert Large, who was Lord Mayor that year and is remembered as the Master of whom Caxton served his apprenticeship. The church was destroyed in the Great Fire of 1666, and rebuilt by Sir Christopher Wren who completed it in 1690.

Over the centuries some exceptionally fine furnishings have been given to St. Margaret's, including the altarpiece, pulpit and font, which have added to the whole. Two paintings of Moses and Aaron flank the high altar, and came from St. Christopher le Stocks when it was demolished in 1781.

The Organ, considered the finest example of English organ building, was built by George England and was opened on Easter Day, 1801. It was restored in 1984, stands in its original case, and contains nearly all its original pipework.
Recitals

Today St. Margaret Lothbury is the church of five Livery Companies, two Ward Clubs and two Professional Institutes, as well as having connections with many local finance houses all of whom hold special services each year.

Each week services of Holy Communion according to the Book of Common Prayer are celebrated on Tuesday at 1.10pm and Thursday (first of the month only) at 12.10pm, and last for around 30 minutes. On Wednesday an informal service of worship with a short address (Celebrate) is held between 12.50 and 2.00pm with people coming and going as work committments demand.

The building is open each day, and a Chapel is available for private prayer. All are welcome to come to any regular service or to the Friday lunchtime meeting.